H2N2V1, France, Analysis, bibRecord, 000312

An antiviral T-Cell clone defines a functional supertypic specificity shared by different HLA-DR molecules from DR2-short , DRw11 , and DRwl3 Haplotypes

Identifieur interne : 000312 ( France/Analysis ); précédent : 000311; suivant : 000313

An antiviral T-Cell clone defines a functional supertypic specificity shared by different HLA-DR molecules from DR2-short , DRw11 , and DRwl3 Haplotypes

Auteurs : Dominique Zeliszewski [France] ; Ghislaine Sterkers [France] ; Jeanine Choppin [France] ; Catherine Freidel [France] ; Lucette Gebuhrer [France] ; Hervé Betuel [France] ; Jean Paul Levy [France]

Source :

Immunogenetics [ 0093-7711 ] ; 1987-02-01.

RBID : ISTEX:7539DD7B22792842598CABF3A9341E6ABEABC8F2

English descriptors

Teeft :
- Ascitic fluids, Assay, Betuel, Broad class, Cell activation, Cell line, Cell lines, Clone, Different haplotypes, Different molecules, Differential blockings, Dr2sh, Drwl3, Drwl3 cells, Drwl3 haplotypes, Drwll, Epitope, Freidel, Functional epitope, Functional inhibition studies, Functional supertypic specificity, Further studies, Gene products, Haplotype, Human class, Ilr2, Immunol, Influenza, Influenza virus, Influenza viruses, Jouph, Larger panel, Lymphocyte clones, Molecule, Monoclonal antibodies, Negative control, Other hand, Page patterns, Phylogenic relationships, Proliferation, Proliferation assays, Proliferation inhibition experiments, Specific response, Sterkers, Supertypic, Supertypic specificities, Triplicate cultures, Viral, Viral antigen, Viral specificity, Viral specificity patterns, Zeliszewski.

Abstract

Abstract: An influenza virus-specific HLA class IIrestricted human T4+ clone (Ij) allows us to define a new functional supertypic HLA class II specificity shared by three different haplotypes. Influenza A virus-infected antigen-presenting cells of these three haplotypes, HLA-DR2 short, DRw11, and DRw13, are able to stimulate Ij cells. The same precise viral specificity is seen in all three cases. Proliferation inhibition experiments using HLA-specific monoclonal antibodies demonstrate that HLA-DR products are involved in all cases. However, according to the DR specificity of the antigen-presenting cell, differential blockings by a series of DR-specific monoclonal antibodies suggest that the functional epitope is shared by different HLA DR molecules. This is confirmed by two-dimensional gel analysis of the HLA DRβ chains expressed in the three haplotypes.

Url:

https://api.istex.fr/ark:/67375/1BB-424TJ0B9-0/fulltext.pdf

DOI: 10.1007/BF00364272

Affiliations:

Links toward previous steps (curation, corpus...)

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ISTEX:7539DD7B22792842598CABF3A9341E6ABEABC8F2

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: An influenza virus-specific HLA class IIrestricted human T4+ clone (Ij) allows us to define a new functional supertypic HLA class II specificity shared by three different haplotypes. Influenza A virus-infected antigen-presenting cells of these three haplotypes, HLA-DR2 short, DRw11, and DRw13, are able to stimulate Ij cells. The same precise viral specificity is seen in all three cases. Proliferation inhibition experiments using HLA-specific monoclonal antibodies demonstrate that HLA-DR products are involved in all cases. However, according to the DR specificity of the antigen-presenting cell, differential blockings by a series of DR-specific monoclonal antibodies suggest that the functional epitope is shared by different HLA DR molecules. This is confirmed by two-dimensional gel analysis of the HLA DRβ chains expressed in the three haplotypes.</div>
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An antiviral T-Cell clone defines a functional supertypic specificity shared by different HLA-DR molecules from DR2-short , DRw11 , and DRwl3 Haplotypes

An antiviral T-Cell clone defines a functional supertypic specificity shared by different HLA-DR molecules from DR2-short , DRw11 , and DRwl3 Haplotypes

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

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